Symbol
Name
ID

Nr0b1
nuclear receptor subfamily 0, group B, member 1
MGI:1352460

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating cortisol level	Adrenal hypoplasia	Adrenal insufficiency	Primary adrenal insufficiency	Decreased circulating aldosterone level	Absence of pubertal development	Delayed puberty	Precocious puberty	Hypogonadotropic hypogonadism
Disease(s) Associated with NR0B1
X-linked adrenal hypoplasia congenita

Mouse Phenotypes

retention of the adrenal gland x-zone

increased Sertoli cell proliferation

endocrine/exocrine gland phenotype

polyovular ovarian follicle

abnormal testis morphology

rete testis obstruction

abnormal peritubular myoid cell morphology

decreased number of peritubular myoid cells

abnormal seminiferous tubule epithelium morphology

ectopic Sertoli cells

dilated seminiferous tubule

seminiferous tubule degeneration

abnormal Sertoli cell development

abnormal testis cord formation

disorganized testis cords

abnormal Leydig cell morphology

abnormal fetal Leydig cell differentiation

ectopic Leydig cells

increased Leydig cell number

decreased testis weight

small testis

increased testis tumor incidence

Availability

Mouse Genotype

Nr0b1^tm1.1Lja/Nr0b1^tm1.1Lja

Nr0b1^tm1.1Lja/Y

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23